domenica 15 settembre 2013

Discovering rare diseases: chloroma

http://www.ajronline.org/doi/full/10.2214/ajr.178.2.1780319


Granulocytic sarcoma, also known as chloroma or extramedullary myeloblastoma, is a rare solid tumor composed of primitive precursors of the granulocytic series of WBC that include myeloblasts, promyelocytes, and myelocytes [1]. This tumor was first described by Burns in 1811. In 1853, King initially called it chloroma, because typical forms have a green color caused by high levels of myeloperoxidase in these immature cells. Rappaport renamed it granulocytic sarcoma in 1966, because not all of the cells are green; 30% are white, gray, or brown, depending on the state of oxidation of the pigmented enzyme or the different cellular enzyme concentrations [12]. Radiologic descriptions of granulocytic sarcomas are rare in the literature and consist mainly of case reports. The aim of this article is to present an overview of the most common imaging findings of granulocytic sarcoma.


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