domenica 26 maggio 2013

EFNS review on the role of muscle biopsy in the investigation of myalgia

l'articolo è stato inserito nella casella condivisa!

Buona lettura

An Updated Definition of Stroke for the 21st Century

nuove linee guida AAN

Buona lettura!


The European Commission has given its approval to the oral factor Xa inhibitor rivaroxaban (Xarelto, Bayer Pharma/Janssen Pharmaceuticals) for secondary prevention in adult patients who have had biomarker-confirmed acute coronary syndrome (ACS), The indication is for 2.5-mg twice daily in combination with standard antiplatelet therapy.

Reference: ATLAS ACS 2 TIMI 51 trial

domenica 19 maggio 2013


La nuova "Bibbia della Psichiatria"è ufficialmente disponibile
ecco il link al sito "American Psichiatry Association"

domenica 12 maggio 2013

FDA Drug Safety Communication: Valproate Anti-seizure Products Contraindicated for Migraine Prevention in Pregnant Women

Blue Person Syndrome

The US Food and Drug Administration (FDA) issued a drug safety communication on April 26, 2013, alerting the medical community that ezogabine (Potiga™; GlaxoSmithKline, Research Triangle Park, North Carolina), one of the newest antiepileptic drugs, may cause blue-gray skin discoloration and retinal pigment changes.


Ezogabine, formerly known as retigabine, received FDA approval as Potiga for adjunctive treatment of partial-onset seizures in adults on June 10, 2011. Ezogabine is a positive allosteric modulator of KCNQ2-5 potassium channels that inhibits high-frequency action potential firing, a unique mechanism of action for an antiepileptic drug.[2] Ezogabine was co-developed by GlaxoSmithKline and Valeant Pharmaceuticals and marketed as Trobalt® in the European Union. An article[3]about ezogabine that included a summary of 2 phase 3 clinical trials appeared in this column shortly after the drug received FDA approval
(fonts: medscape)

domenica 5 maggio 2013

FDA Issues Warning About Antiseizure Drug Potiga

Neurologists and other physicians using the antiseizure drug (ezogabine (Potiga, Valeant Pharmaceuticals) as an adjunct treatment in patients with partial-onset epilepsy should be on the lookout for blue skin discoloration and retinal abnormalities and report these adverse effects should they occur.
The Food and Drug Administration (FDA) has issued a warning that ezogabine can cause pigment changes and eye abnormalities. According to a government press release, it's not known at this time whether these changes are reversible. The FDA said it is working with the manufacturer to gather and evaluate all available information to better understand these developments and will update the public when more information is available.
The FDA recommends that all patients taking ezogabine have a baseline eye examination and periodic eye examinations that should include visual acuity testing and dilated fundus photography. Periodic examinations may include fluorescein angiography, ocular coherence tomography, perimetry, and electroretinography.

Novel Agent Safe, Effective for Parkinson's Psychosis

San Diego, California — A novel, first-in-class, nondopaminergic agent that selectively blocks serotonin 5-HT2A is safe and effective for the treatment of Parkinson's disease psychosis (PDP), new research suggests.
Confirming previously released topline results and reported byMedscape Medical News at that time, the phase 3 placebo-controlled trial showed that the selective nondopaminergic 5-HT2A receptor agonist pimavanserin was significantly better than placebo at reducing PDP.

American Academy of Neurology (AAN) 65th Annual Meeting. Emerging Science Session Abstract 004. Presented March 15, 2013.