FDA Drug Safety Communication: FDA requires label changes to warn of risk for possibly permanent nerve damage from antibacterial fluoroquinolone drugs taken by mouth or by injection

http://www.fda.gov/downloads/Drugs/DrugSafety/UCM365078.pdf

Safety Announcement

[8-15-2013] The U.S. Food and Drug Administration (FDA) has required the drug labels and Medication. Guides for all fluoroquinolone antibacterial drugs be updated to better describe the serious side effect  of peripheral neuropathy. This serious nerve damage potentially caused by fluoroquinolones may occur soon after these drugs are taken and may be permanent. The risk of peripheral neuropathy occurs only with fluoroquinolones that are taken by mouth or by  injection. Approved fluoroquinolone drugs include levofloxacin (Levaquin), ciprofloxacin (Cipro),  moxifloxacin (Avelox), norfloxacin (Noroxin), ofloxacin (Floxin), and gemifloxacin (Factive). The topical  formulations of fluoroquinolones, applied to the ears or eyes, are not known to cause this risk.  If a patient develops symptoms of peripheral neuropathy, the fluoroquinolone should be stopped, and  the patient should be switched to another, non-fluoroquinolone antibacterial drug, unless the benefit of continued treatment with a fluoroquinolone outweighs the risk. Peripheral neuropathy is a nerve  disorder occurring in the arms or legs. Symptoms include pain, burning, tingling, numbness, weakness, 

 r a change in sensation to light touch, pain or temperature, or the sense of body position. It can occur  at any time during treatment with fluoroquinolones and can last for months to years after the drug is stopped or be permanent. Patients using fluoroquinolones who develop any symptoms of peripheral  neuropathy should tell their health care professionals right away.  FDA will continue to evaluate the safety of drugs in the fluoroquinolone class and will communicate with  the public again if additional information becomes available