KCNQ2 encephalopathy: Delineation of the electroclinical phenotype and treatment response

Neonatal-onset epilepsies are rare conditions, mostly genetically determined, that can have a benign or severe phenotype.There is recent recognition of de novo KCNQ2 mutations in patients with severe neonatal-onset epilepsy, with intractable seizures and severe psychomotor impairment, termed KCNQ2 encephalopathy. This is a rare condition and all patients reported so far were diagnosed well after the neonatal period. We report on 3 new cases of KCNQ2 encephalopathy diagnosed in the neonatal period and studied with continuous video-EEG recording. We describe a distinct electroclinical phenotype and report on efficacy of antiepileptic drug (AED) therapies
Neurology 2013